THURSDAY MAY 6

9.00 - 10.30

Registration

10.30 -11.30

Klinefelter Syndrome – across the Lifespan

1

Welcome - A Juul, Denmark

2

Klinefelter syndrome: the forgotten syndrome - NE Skakkebæk, Denmark

3

Morbidity and mortality in KS - A Bojesen, Denmark

11.30 - 13.00

Lunch and posters

13.00 - 14.30

Genetic aspects of 47,XXY

1

Lethal and non-lethal trisomies - S Brunak, Denmark

2

Inactivation of chromosome X - L Carrel, USA

3

Genetic and phenotypic variation in 46,XX and 47,XXY males? Comparisons with focus on the X chromosome - F Tuettelmann, Germany

14.30 - 15.30

Animal models

1

47,XXY mice - RS Swerdloff, USA

2

41,XX^Y* male mice: an alternative model for the Klinefelter Syndrome - J Wistuba, Germany

15.30 - 16.00

Coffee

16.00 - 18.15

Phenotypic variation

1

2

Growth, bone density and body composition in childhood and adolescence - L Aksglaede, Denmark

Insulin resistance and metabolic syndrome in prepubertal boys with KS - Selected oral presentation by M Zeger, USA

3

Body composition and metabolic syndrome in adult KS - CH Gravholt, Denmark

4

Bone density and risk of osteoporosis in Klinefelter syndrome - C Foresta, Italy

5

Autoimmunity in KS - RH Scofield, USA

18.15 - 20.00

Welcome reception

FRIDAY MAY 7

8.45 - 10.30

Testicular and endocrine function in Klinefelter syndrome

1

Sertoli and Leydig cell function in infancy - N Lahlou, France

2

Hypogonadism in childhood - R Rey, Argentina

3

Pituitary-gonadal axis in adolescence - L Dunkel, Finland

4

Pituitary-gonadal axis in adult KS - A Juul, Denmark

10.30 - 11.00

Coffee

11.00 - 12.45

Testosterone treatment in Klinefelter syndrome - Chair AD Rogol, USA

1

Testosterone treatment in infancy and childhood - I Fennoy, USA

2

Testosterone treatment in adolescence - J Ross, USA

3

Adult testosterone treatment - M Zitzmann, Germany

4

Around the table discussion - I Fennoy / J Ross / M Zitzmann / A Juul

12.45 - 14.00

Lunch and posters

14.00 - 16.00

Neuropsychological aspects in Klinefelter syndrome

1

Neurodevelopmental problems in infancy and childhood - C Samango-Sprouse, USA

2

Neurodevelopmental outcomes in a prenatally identified sample of children with sex chromosome trisomies - D Bishop, UK

3

Cognitive and psychological problems in KS - S van Rijn, Holland

4

The parent-of-origin of the extra X chromosome differentially affects psychopathology in KS - Selected oral presentation by H Bruining, Holland

5

Phenotypic characteristics in 48,XXYY and 48,XXXY men - N Tartaglia, USA

17.00 -

Guided tour at Freetown Christiania and Workshop dinner

SATURDAY MAY 8

9.00 - 10.00

Cancer

1

Breast cancer in KS  - LA Brinton, USA

2

Mediastinal germ cell tumours in KS - E Rajpert-De Meyts, Denmark

10.00 - 11.30

Fertility

1

Fertility in KS - G Westlander, Sweden

2

3

Microdissection of testes in patients with KS - T Ishikawa, Japan

Fertility treatment in KS - genetic counselling - C Staessen, Belgium

11.30 - 13.00

Lunch and posters

13.00 - 14.15

Counselling and screening

1

Counselling of parents expecting a child with KS - how to advise - C Girardin, Canada

2

A population based study of the psychosocial impact of KS & attitudes towards diagnosis and screening - Selected oral presentation by A Herlihy, Australia

3

Postnatal screening for KS – is there a rationale? - RI McLachlan, Australia

14.15 - 14.45

General discussion

Chaired by A Juul and others

14.45 - 15.15

Goodbye coffee