Male Reproductive Health Study

 

In Denmark, all young men, except those suffering from severe or chronic diseases (<15%), are required to attend a medical examination before they may be considered for military service.

 

In collaboration with the military health authority, young men attending these medical examinations in the greater Copenhagen area in Denmark are asked to participate in The Male Reproductive Health Study. Those men who consented to participate were examined at the Department of Growth and Reproduction at Rigshospitalet, Until now, more than 6000 young men have been included in the study.

For details on the examination, and samples taken, see the column to the left.

 

Inclusion criteria

The young men are invited irrespective of whether they were declared fit for military service.

Place of residence should be in the greater Copenhagen area

 

Ethical aspects

The study was approved by ethical committees of the Capital Region (RegionH) and in accordance with the Helsinki II declaration. All participants gave their informed consent.

 

Principal investigator

Senior scientist and Consultant Niels Jørgensen

 

Investigators

Inge Ahlmann Olesen MD

Loa Nordkap MD

Peter Christiansen MD

Tina Kold Jensen MD, PhD, Prof

Ulla Nordström Joensen MD

Anne-Kirstine Bang MD

Lærke Priskorn MPH

Marianna Krause MD

Pia Ekbom MD

Niels E Skakkebæk, MD, Prof

 

 

 

For publications related to the Male Reproductive Health Study, see here

 

 

The study gathers the following information:

 

Physical examination

Height

Weight

Degree of masculinization

External genitals

Testicular size

Testicular ultrasound

Gynaecomastia

DEXA scan*: Bone mineral density,  body fat mass etc.

Anogenital distance*

Blood pressure*

 

Semen samples

Sperm concentration

Total sperm count

Motility

Morphology

CYP-24A1*

Cholesterol*

Phthalates*

 

Blood samples

FSH and LH

Testosterone

Estradiol

SHBG

Inhibin B

AMH*

INSL3*

IGF-1 and IGFBP3*

Albumin

Cholesterol*

Calcium*

Alcaline phosphatase*

PTH *

25-OH-vitamin D*

DNA and RNA isolation Genetic polymorphisms* (AR, FSHB, FSHr, IGF, SHOX, R501X, 2282del4)

Whole genome SNP analyses (Affymetrix)*

PCBs*

PFCs*

 

Urine sample

Parabens*

Phthalates*

Bisphenol A*

Triclosan*

UV filters*

 

Questionnaire

Previous health and growth Socio-economic factors

Lifestyle factors

Diet

 

*=available for a subgroup and/or later included participants